Functional reconstruction of total lower lip defect with mental neurovascular V-Y advancement island flap / 中华口腔医学杂志

<p><b>OBJECTIVE</b>To introduce a method of functional reconstruction for total lower lip defects.</p><p><b>METHODS</b>Six patients with lower lip cancer were treated by surgery from November 2007 to February 2009. The full thickness defects with a size from eighty percent to total lower lip were reconstructed with two triangular mental neurovascular island flaps of chin. The musculocutaneous and mucous flaps with neurovascular pedicles were advanced in a V-Y manner to close the defect and reconstruct the orbicularis oris muscle.</p><p><b>RESULTS</b>All flaps survived and no recurrence and complication were observed and showed excellent cosmetic and functional results over 6 months of follow-up. The reconstructed lower lips provided a wide-enough mouth opening, and the sensation of oral mucosa and the muscle function of oral sphincter were preserved.</p><p><b>CONCLUSIONS</b>The technique of mental neurovascular V-Y advancement island flap can get satisfactory results in both functional and the aesthetic perspects.</p>

Inhibition effect of glycyrrhizin on transplanted mandibular gland fibrosarcoma of mice / 华西口腔医学杂志

<p><b>OBJECTIVE</b>To study glycyrrhizin's anticancer effect and its mechanism.</p><p><b>METHODS</b>3-methylcholanthrene were injected into mice's submandibular glands to induce tumor, then transplanted the tumor pieces (1 mm3) to mice. The transplanted tumors were measured, and flow cytometry analysis and cytomorphology observation were conducted.</p><p><b>RESULTS</b>Glycyrrhizin (GL) inhibited the transplanted mandibular gland fibro-sarcoma of mice and the suitable GL dose for inhibiting fibrosarcoma of mice was 1.61 mg per 20 g weight. The GL dose below 3.22 mg per 20 g weight didn't produce remarkable toxicity and side effects. GL induced cytomorphological changes of tumor cells and enhanced immunosuppression of macrophage on fibrosarcoma. The result of flow cytometry showed that tumor cell counts of GL1 and GL2 groups increased remarkably in DNA synthetic prophase, and decreased in DNA synthetic phase.</p><p><b>CONCLUSION</b>GL can inhibit transplanted mandibular gland fibro-sarcoma of mice. The anticancer mechanism of GL may be acting on related enzymes with phagocytosis. The result of flow cytometry showed that the shift of fibrosarcoma cells from G1 phase to S phase was blocked. This suggests that the anticancer action of GL is related to its inhibition of ribonucleotide reductase, a rate-limiting enzyme in DNA synthesis.</p>